Long COVID

Multiple early factors anticipate post-acute COVID-19 sequelae

Over two years into the global pandemic, the scientific community has stepped up investigations into what is commonly referred to as “long COVID,” or health conditions resulting from the disease. Specifically, we are interested in (1) predictors of long COVID and (2) what factors affect a patient who continues to grapple with post-COVID symptoms and health impacts.

Recent studies have provided clues as to what might drive this condition with the goal of identifying intervening factors that can either prevent or reverse long-COVID. In one of the first systematic studies to address long-COVID, we performed a longitudinal multi-omic analysis of over 200 individuals who were following several months post-acute infection. We identified several factors associated with long-COVID, including pre-existing conditions and the presence of certain autoantibodies. Clinical efforts like this study are crucial in understanding the complex biology of long-COVID, which, in turn, will help us understand how to improve patient outcomes.

Results roundup:

  • Longitudinal multi-omics associate Post-acute sequelae of COVID-19 (PASC) with auto-antibodies, viremia, and comorbidities
  • Reactivation of latent viruses during initial infection may contribute to PASC
  • Subclinical auto-antibodies negatively correlate with anti-SARS-CoV-2 antibodies
  • Gastrointestinal PASC uniquely present with post-acute expansion of cytotoxic T cells

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