The Human Phenome Initiative
Building a national scientific infrastructure and partner ecosystem to understand, predict, and improve human health.
introduction
Medical science has invested heavily to understand and treat disease. We have not invested equally to understand health and resilience.
For the first time, advances in longitudinal measurement technologies, systems biology, and artificial intelligence make it possible to understand health as a dynamic system and to identify transitions toward disease far earlier than ever before.
We have made significant progress in understanding disease, but still know remarkably little about:
01
Why some people remain healthy for decades.
02
Why health trajectories diverge for different people.
03
How health to disease transitions begin.
04
How to detect those transitions earlier.
As a result, we often intervene too late. The next frontier is understanding health itself.
Why now is the right time
Three breakthroughs are converging
Together, these advances enable predictive health not previously possible.
Next-generation measurements
Leverage technologies to explore new dimensinos of health more deeply.
Systems biology
The ability to understand health as a dynamic system rather than isolated events.
Artificial intelligence
New computational capabilities that can decipher biological complexity at unprecedented scale.
What the Initiative will accomplish
The Human Phenome Initiative will create:
Phenome Health's Discovery approach
We are building the systems to harmonize existing large data with new studies to create the building blocks required for the Human Phenome Initiative
01
Human health data
Integrate multimodal biological, behavioral, digital health, and environmental data from proprietary and public sources.
02
Data harmonization
Create global data interoperability for harmonization across sources to increase power for discovery.
03
Contextual mapping and analysis
Systems analysis to predict health trajectories and inform tailored interventions.
Health industry partners
4.1
Clinically validated interventions
Drive improvements in health outcomes
Research partners
4.2
Hypothesized actionable possibilities
Identify novel putative causal paths
Why Phenome Health is the right organizing force
A CEO, Lee Hood, recognized as a global leader and innovator
50+ year track record of thought leadership with over 1,000 scientific papers
Successful catalyst for seeding companies technologies with a network of high-level leaders across relevant industries
Trusted with hundreds of millions in career research funding
Existing projects and partners in place as the foundational building blocks of the HPI
Active partnerships with national participant recruitment networks, bioassay technology companies, and digital health leaders
$50M+ in funded projects generating deep longitudinal phenomic data across health and disease
Computational platform built for scale with integrated knowledge graphs and multiomic data assets
The Human Phenome Initiative cannot be built by one organization alone. We are seeking partners who can help build the scientific ecosystem for predictive health.
AI & Technology Leaders
Build the computational foundation for predictive health.
Government & Policy Leaders
Create a national scientific asset with long-term societal impact.
Population & Health System Partners
Recruit and engage diverse populations while bringing new capabilities to communities.
Philanthropists
Contribute funding for foundational projects as keystone building blocks.
Academic & Community Partners
Bring scientific expertise and thought leadership.
